Plague Inc. Artificial Organs Scenario: Virus Mega-Brutal (3 Biohazards) Guide & Walkthrough

The Virus plague is one of the seven available plagues to finish the Artificial Organs scenario. This guide works with mega-brutal difficulty. If you'd rather use a different plague to finish the scenario, Click here for available guides.

Update: I made this guide for brutal difficulty but it also works for mega-brutal. Please post questions you might have if it does not work for you.

Beating the Artificial Organs scenario with the Virus plague is somewhat difficult because of the Virus' nature that causes it to uncontrollably mutate symptoms. I've done several trial and error games in order to accomplish this guide. As you may already know, we need to finish this plague in brutal/mega-brutal difficulty to attain a 3 gold biohazards for the scenario. To do just that we'll need to finish with a 5 out 5 biohazard score at the end of the game.
At first try, you might come to a conclusion that accomplishing a 5 out 5 biohazard score for this plague is impossible. I thought that too. Because of the random mutations, you've probably faced problems such as countries closing their point-of-entries too soon.

In the Artificial Organs scenario, you are faced with people who have all replaced their organs with artificial ones. What happens in this scenario is lethality is significantly reduced because of organ replacements but don't fret there is actually a symptom to counter this, Insanity. Insanity makes people rip out their artificial organs making it artificial organs a non-factor anymore.

In this guide we'll let the virus freely mutate as it wishes. At the start, we'll be focused on spreading the infection as quickly as possible. Don't worry if your Virus mutates a lethal symptom at the start, we actually want that to happen. Just continue to evolve symptoms, abilities, and transmissions I tell you to and you'll see that beating this plague is actually pretty easy.

Now onto the guide.

Gene setup:

  • ATP Boost
  • Teracyte
  • Sympto-Stasis
  • Darwinist
  • Extremophile
1.) Before selecting a country to start in, evolve the following symptoms:
  • Cysts
  • Hyper Sensitivity
  • Abscesses
  • Anaemia
2.) Start in China then continue to evolve the following symptoms:
  • Haemophilia
  • Nausea
  • Vomiting
  • Rash
  • Sweating
  • Coughing
  • Pneumonia
  • Sneezing
3.) As soon as you have enough DNA evolve the following transmissions:
  • Water and Air 1
  • Water and Air 2
  • Extreme Bioaerosol
4.) Move onto abilities, evolve them in this order:
  • Drug Resistance 1 and 2
  • Cold and Heat Resistance 1
  • Cold and Heat Resistance 2
  • Environmental Hardening
5.) At this point we'll be going back to evolving symptoms. Some of these symptoms might have already mutated, if that's the case then just skip them. If you can't see these symptoms on your tree, you'll have to evolve lower tier symptoms first. I'll include the best path to these symptoms to help you out.
  • Insanity (Insomnia-Paranoia-Seizures)
  • Necrosis (Rash-Sweating-Skin Lesions)
  • Coma (Cysts-Hyper Sensitivity-Paralysis)
  • Total Organ Failure (this is immediately unlocked by evolving Coma)
  • Hemorrhagic Shock (you'll see this upon evolving Necrosis)
  • Internal Hemorrhaging (below Hemorrhagic Shock)
  • Systemic Infection (below Coma, on the right side)
6.) The symptoms above are all you're going to need in terms of lethality. Remaining DNA is best used to evolve Genetic Re-Shuffles.

There you go, I hope you managed to achieve a 3 golden biohazard score for the Artificial Organs Scenario. By using this strategy, I was always able to finish within 300 days. I believe that a 5 out 5 biohazard score is best achieve by finishing within 365 days. I'm not so sure about this yet.

If you've got any questions, tips, and/or strategies you'd like to share with us, post them at the comments below. I'll include the good ones along with this guide. Thanks for reading and Happy spicy gaming!


  1. Awesome strat.

    377 days, cure 26% and got 3 biohazards, got really lucky with mutations though.

  2. 266 days 16% cure works like a charm first time 3 biohazards

  3. Gene setup? And how do you mutate without choosing a country?

  4. Genes from the Genetic Code page that will help make the game easier.

    You can mutate before you even start in a country by going to the abilities page. This can be done on the mobile version of the game(iOS), not quite sure on other platforms, though.

  5. Oh okay. Thanks. Srry. I was just kinda confused. :)