Plague Inc. Big Bang Achievement Guide & Walkthrough

The Big Bang achievement is one of the many achievements that can be unlocked by playing on the Necroa Virus plague. Your starting country must always be the USA to unlock any DarkWater-related achievements. In order to unlock this achievement, you must complete and react to different pop-up events that happen as the game progresses.

Credits to this site for providing the strategy for this achievement. I've only made a few changes and added some pictures to help identify the pop-ups you'll need to see.

It is highly recommended to attempt unlocking this achievement in casual difficulty. It is also possible to unlock it higher difficulties but you will have much more trouble with Z-Com and the slow rate of infection. In order to trigger the first event that leads to the final pop-up of this achievement, we must start the Necroa Virus in the USA and evolve an ability and transmission within the first 60 days.

Here's the recommended gene setup:

  • Cytochrome Surge
  • Aerocyte
  • Spliced Activation
  • Based Oxidisation
  • Hydrophile

1.) Start in the USA. Evolve Saliva 1 and Drug Resistance as soon as you can. These two will cost 6 and 9 DNA, respectively.

2.) If you've successfully evolved the ability and transmission mentioned above within 60 days, this pop-up should appear:
DarkWater 'concerned' for missing geneticist

3.) Gather up DNA and keep an eye on the news banner. There are times when these news fail to appear on the news headlines on the world screen, so be sure to manually check the news as well.
DarkWater denies containment breach in weapons facility
DarkWater weapons facility shut down over security fears

4.) After seeing both news headlines above, evolve the following:

  • Insomnia
  • Fever
  • Photophobia
  • Delirium
  • Cytopathic Reanimation
Zombies should start appearing at this point. After a while a pop-up should appear:
[1.1] DarkWater created [plague name]

5.) From this point on, you'll have to remember a few things to make sure you don't fail.

  • Prevent the zombie population of the USA from exceeding 5 million. To prevent too much zombies from appearing, use the Zombie Horde ability by evolving Horde Pheromones and adding abilities that increase the zombie horde size. It's best to move zombies once the population reaches 4 million.
  • If you get a pop-up saying "Authorities can't protect from the USA" this means that you'll have to start the game over. If that pop-up appears, DarkWater events won't show up anymore.

6.) There are a number of pop-ups that we'll need to wait for before we evolve anything. Remember the things I mentioned above.

The first pop-up that appears after [1.1] should be this one:
[1.2] DarkWater successfully analyses [plague name]
Right after [1.2] this pop-up follows:
[1.3] DarkWater begin Z-REST experiment

7.) After seeing the pop-up above, [1.3], evolve the following:
  • Anaerobic Resuscitation
  • Enhanced Motor Control
  • Peptide Surge
  • Acidic Reflux
  • Naja Mortis
  • Autothysis
Wait a few moments then the final pop-up should appear:
DarkWater's Z-REST device a failure
This pop-up marks the successful unlocking of the Big Bang achievement. You can now choose to quit or finish the game.

Thanks for reading this guide and HSG!


  1. I follow the guide, but every time I get to the first Z-REST pop-up I'm not able to evolve all the symptoms in time, and I get the "Z-REST Success" pop-up.
    Any suggestions?

  2. This was my guide that worked.

    Metabolic Jump
    Spliced Activation
    Based Oxidisation

    Infect USA

    Saliva 1

    Drug Resistance 1

    Gastrointestinal Expansion

    Wait for all the pop ups like usual


    I waited to evolve Delirium and Cytopathic Reanimation until the cure was at 5%.
    (I had 140 DNA, Cure at 5% and only 5 countries uninfected)

    Evolve Delirium and Cytopathic Reanimation now

    Evolve all Horde abilities.
    More zombies from USA when it hits 2 million

    Wait for pop ups again. Cure will get pretty high but you'll have enough DNA once the pop ups come up it wont matter (120 or higher)


    I couldn't get enough DNA by following this guide directly so I added a few things. It just infects more people so more DNA points are available.

    Note: If they start researching early don't worry about the horde abilities but it does help either way.

  3. This worked first go... Great Guide!!!!

  4. Thanks! Works great on Android and iOS!

  5. Worked perfectly first try, thanks!

  6. I've tried this three times, and every game, the cure progresses faster than the pop ups show up. The cure gets to 100% before the Z-REST pop-up shows up. I even tried using Genetic Memic on the third try, and it didn't work.