Plague Inc. Bacteria Speed Run Guide | 5 Biohazard Strategy

This is my very first speed run guide, so why not start it with the easiest plague type there is, Bacteria. I think speed run difficulty is set on Normal(maybe brutal?), because it's easier than what I've faced on several mega-brutal difficulty games. Strategy I used is pretty simple, focus on symptoms at start then evolve some abilities and transmissions, kill the world.

As the game mode suggests, speed run is all about finishing fast and that's all there is to it. There are no stats at the end of the game besides the number of days you finished, so hurray for no cure progression!

Be prepared to make some changes on the strategy, there are a lot of factors in-game that affect your overall success, such as sanitation events, watchlist placements, and other events. Using this strategy, I was always able to finish within 300 days--the final game I did finished at 300+ because I decided to be fancy and ended up infecting Greenland near the end.

Tips are very much appreciated, so don't be shy and post them at the comments below!

Let's get to it.


  • ATP Boost
  • Aerocyte
  • Sympto-Stasis 
  • Genetic Mimic
  • Extremophile
I chose genes that would benefit me right from the start, because I want to be able to get my infectivity high right away.

1.) Start in Saudi Arabia. Evolve the following in this order:
  • Coughing
  • Sneezing
  • Cysts
  • Abscesses
  • Hyper-sensitivity
  • Rash
  • Sweating
  • Air 1
  • Water 1
  • Air 2
  • Pneumonia
  • Drug Resistance 1
  • Cold Resistance 1 & 2
  • Pulmonary Oedema
  • Diarrhoea
Evolving symptoms early will provide the much needed infectivity to be able to infect new countries fast, while also providing more DNA from red and orange bubbles because of increased severity. 

TIP: Make your own call regarding mutations, if it's good or you're about to evolve it anyway, just keep it. Otherwise, if it's bad, just devolve and get some extra DNA out of it.

2.) Continue by evolving the following in this order:
  • Water 2
  • Skin Lesions
  • Necrosis
  • Extreme Bioaerosol
  • Drug Resistance 2
  • Paralysis
  • Coma
  • Total Organ Failure
  • Insomnia
  • Paranoia
  • Seizures
  • Insanity
  • Nausea
  • Vomiting
  • Pulmonary Fibrosis
  • Dysentery
All the transmissions, abilities, and symptoms above will start killing people at an okay rate for Necrosis, they will also slow down the cure and provide more infectivity. Some might argue that we don't need the cure slowing symptoms, but Insanity provides a decent boost in infectivity as well as cure slowing, and the other symptoms are...I don't know...cool?

3.) After evolving Dysentery, we'll move back to evolving abilities for a bit to give our Bacteria some time to completely overrun the world. Evolve the following in this order:
  • Bacterial Resilience 1, 2, & 3
  • Heat Resistance 1
These abilities will provide a little bit more infectivity in every country, especially on the African continent countries which might show a slow infection rate--I'm looking at you, Morocco. Right after evolving Heat resistance, there is no need to wait for the whole world to be infected, evolve these lethal symptoms right away.
  • Hemorrhagic Shock
  • Internal Haemorrhaging
  • Systemic Infection
  • Tumours
At this point, evolve what you want, evolve every single symptom maybe?

By using this strategy, I was able to get a high score of 267 days. Here's the summary from the last 3 games I did using this strategy.
The first game, I was still experimenting with the strategy, going for transmissions first then moving onto symptoms right after.

On the second game, I did the exact same strategy above and got my record score.

The third game, I was unable to infect Greenland right away. I was almost at the end of the game before an infected ship managed to get through to it. It was partially my fault because I neglected to evolve Water 1, thinking that forgetting it would make the game faster. Needless to say, I was wrong.

So that about does it for this guide, thanks for reading and I hope this guide has helped you guys complete Bacteria Speed Run with a 5 biohazard score. Again, tips and other advice are very much appreciated, so post them at the comments below! 


  1. First time I didn't infect Greenland. Second time I modified it a bit (skipped insanity and left bacterial resistance until later) and got 286.

  2. Swap Genetic Mime for Darwinist for obvious reasons. The speed run is set as a normal game (not brutal)

  3. Ps. is worth trying the same strategy with native bio and xerophile to see if its faster

  4. Ps2: using this strategy: http://forums.toucharcade.com/showpost.php?p=2922950&postcount=3075

    You can beat it in almost 200 days

  5. ps3: I think your strategy works wonders on mega-brutal games and is more suited to them than this one I posted, but for speed runs which are set in normal this kinda of path is way better

  6. Yeah, I was kinda just using my mega-brutal formula for the speed runs. Will definitely focus more on speed and less on cures on future speed run guides.

    This is actually the first speed-run game I did(besides Simian), and I was too used to playing on mega-brutal.