Plague Inc. [Submitted Guide] Global Warming Mega-Brutal 3 Biohazard Guide

This guide has been written and submitted by Marcus Slade. Submit your own guide to us now via our submit section or by sending them directly to us through our email.

Spicy's Comments: It wasn't specified which plague type should be used with this strategy but I think it would work well with Bacteria, Parasite, and Prion. Mainly because these plagues are closely related without the use of their own unique abilities. Remember to comment and give your feedback on this guide for its improvement.

Global Warming Mega-Brutal 3 Biohazards
First off, it's gonna depend partially on luck. Most of you will know this already. 

Next, totally ignore any mutating symptoms. Other than scaring the islands, even lethal ones will work to your benefit. Early mutations help but are not required for victory, but may be necessary for 3 Biohazards instead if just 2.


Air 1 is mostly because on my first success, air filters popped up almost immediately and I didn't have a choice. You may not need to get it.


If Insanity and Coma are already available, feel free to get those first to cut back on the cure, then get Insomnia, Paranoia, Seizures, and Paralysis to slow down research.


It may seem obvious or unimportant to some of you, but getting Heat Resistance ASAP really is key, especially in the first few moments to get that infection started. Speed is what you need to get 3 Biohazards. 
If all you want is a victory, this or several other guides will get you there.

Gene Setup:

• ATP Boost
• Aquacyte
• Sympto-Stasis
• Genetic Mimic
• Extremophile

1. Start in China
2. Evolve Heat Resistance 1
3. Evolve the following symptoms: Nausea, Coughing, Rash, Cysts, Anaemia, Vomiting, Pneumonia, Sneezing, Sweating, Hyper Sensitivity, Abscesses, and Haemophilia
4. Evolve Water and Insect 1
5. Evolve Air 1
6. Evolve Water and Insect 2
7. Evolve Heat 2
8. Evolve Cold, and Drug Resistance 1 & 2 then Environmental Hardening
9. Evolve the following symptoms if they have not mutated yet: Diarrhoea, Dysentery, Skin Lesions, Pulmonary Oedema, and Necrosis
10. Evolve Genetic Hardening 1 and 2
11. Evolve these symptoms if they have not mutated: Insomnia, Paranoia, Seizures Insanity, Paralysis, and Coma
12. Wait until everyone is infected by your plague, then evolve every lethal symptom you can
13. Use Genetic Re-Shuffles if you think it's necessary