Plague Inc. [Submitted Guide] Global Warming Mega-Brutal 3 Biohazard Guide

This guide has been written and submitted by Marcus Slade. Submit your own guide to us now via our submit section or by sending them directly to us through our email.

Spicy's Comments: It wasn't specified which plague type should be used with this strategy but I think it would work well with Bacteria, Parasite, and Prion. Mainly because these plagues are closely related without the use of their own unique abilities. Remember to comment and give your feedback on this guide for its improvement.

Global Warming Mega-Brutal 3 Biohazards
First off, it's gonna depend partially on luck. Most of you will know this already. 

Next, totally ignore any mutating symptoms. Other than scaring the islands, even lethal ones will work to your benefit. Early mutations help but are not required for victory, but may be necessary for 3 Biohazards instead if just 2.

Air 1 is mostly because on my first success, air filters popped up almost immediately and I didn't have a choice. You may not need to get it.

If Insanity and Coma are already available, feel free to get those first to cut back on the cure, then get Insomnia, Paranoia, Seizures, and Paralysis to slow down research.

It may seem obvious or unimportant to some of you, but getting Heat Resistance ASAP really is key, especially in the first few moments to get that infection started. Speed is what you need to get 3 Biohazards. 
If all you want is a victory, this or several other guides will get you there.

Gene Setup:

  • ATP Boost
  • Aquacyte
  • Sympto-Stasis
  • Genetic Mimic
  • Extremophile

  1. Start in China
  2. Evolve Heat Resistance 1
  3. Evolve the following symptoms: Nausea, Coughing, Rash, Cysts, Anaemia, Vomiting, Pneumonia, Sneezing, Sweating, Hyper Sensitivity, Abscesses, and Haemophilia
  4. Evolve Water and Insect 1
  5. Evolve Air 1
  6. Evolve Water and Insect 2
  7. Evolve Heat 2
  8. Evolve Cold, and Drug Resistance 1 & 2 then Environmental Hardening
  9. Evolve the following symptoms if they have not mutated yet: Diarrhoea, Dysentery, Skin Lesions, Pulmonary Oedema, and Necrosis
  10. Evolve Genetic Hardening 1 and 2
  11. Evolve these symptoms if they have not mutated: Insomnia, Paranoia, Seizures Insanity, Paralysis, and Coma
  12. Wait until everyone is infected by your plague, then evolve every lethal symptom you can
  13. Use Genetic Re-Shuffles if you think it's necessary


  1. Doesn't work (finishes between 450 ~ 500 days(

  2. At least on mega brutal

  3. Tried .. Didn't work to finish w/ 3* biohazard

  4. Ah crap, forgot to mention that I've only tried it with virus. It will work, but as usual, some is gonna just depend on luck. Either getting all the islands, or fast enough infection. Whenever I got all the countries infected though, I would always get 2-3 Biohazards.

  5. It worked! I tried this on virus, and finished at 406 days. Awesome guide!

  6. 3 Biohazards... I forgot to mention that

  7. I finished this on 375 days with 35% cute progression by following the mega brutal guide for nano virus and altering it to suit the changed climates (introducing heat resistance early on). It took a couple of attempts to work out, but it seems pretty solid. I'll have to try it another couple of times to work out the exact order.

  8. I hope this helps

  9. Hope this helps