Yo It's Spicy: Plague Inc.[Submitted Guide] Plague in Space Achievement Guide

This guide has been written and submitted by katrina. Submit yours to us now!

Spicy's Comments: Amazingly done guide by katrina! Includes screenshots for easier following. Remember to rate and comment for the guide's improvement. It can be used for other achievements as well!

This guide can also be used to achieve Patient WHO, and Russian Nuclear Reaction

I've tested this guide only 3 times, and have been able to achieve all three achievements in a single game once with it. I've been able to achieve both the nuke & plague in space every time though. Please try it out and do what you can to make it better.

Plague In Space Achievement Guide

It's important to note that you need to have patience between the pop-ups. Sometimes the astronauts will die at 1.5 billion deaths, sometimes not til after 3 billion.

You can also achieve Patient Who and Russian Nuclear Retaliation with this guide. When Spalin threatens Russia, evolve Paralysis. 'Patient who' can just happen following this guide, but sometimes the CDC finds them too quickly. If you want to use this guide for Patient Who, when the CDC says they are zeroing in on USA, immediately evolve dysentery, seizures, and inflammation.

Note : devolve ANY symptoms that mutate. Lethal or non lethal.

Genetic Setup

Catalytic Switch - This is the MOST important of all genes. You will be doing quite a bit of waiting, and you're going to NEED the DNA from cure bubbles. And there will be plenty.
Aerocyte - I think it's correlated to achieving the Plague In Space. One game I played using Aquacyte did not trigger the first pop up, but perhaps I missed a step.
Sympto-Stasis - We will be evolving then devolving then again evolving many symptoms. Unless you want to pay 30+ DNA just for inflammation, I suggest using this.
Genetic Mimic - Slow down the cure even further, as we will be patiently waiting for quite some time.
Extremophile - I almost always use this anyway. Pick whichever.

1.) Use Prion on casual difficulty

2.) Start in USA, then evolve

Drug 1
Air 1 & 2
Cold 1
Drug 2
Water 2 & 3
Extreme Bioaerosal
Neural Atrophy 1, 2& 3
Genetic Hardening 1 & 2

Make sure you devolve ANY symptoms until every country (Morocco should be last )in the world is infected

2.) Now that every country is infected, it's okay to let symptoms mutate but devolve ANY somewhat lethal symptoms or Skin Lesions if they mutate. We don't want the profuse bleeding combo.

Evolve every first symptom, and then every second branch symptom. Order isn't important but I usually do this

Insomnia
Paranoia
Cysts
Anaemia
Rash
Nausea
Coughing
Sweating
Vomiting
Sneezing
Pneumonia
Hyper sensitivity
Abscesses
Haemophilia

Note: To nuke Russia, also evolve cold 2. To nuke China, evolve bird 1&2

3.) Save at least 23 DNA
Evolve Seizures & Insanity at the same time, and then immediately devolve seizures. Do not let anyone die.
Remember to Devolve ANY symptom other than those listed. This is what you want to see in your Symptoms tree

Symptom tree at this point

We do not want folks dying... Yet.

So now we wait until we see this pop-up

There's been times where I haven't seen this pop up til 60%. Be patient!

4.) Now we need to devolve devolve devolve.
Devolve EVERY symptom EXCEPT Insomnia, paranoia, and insanity. You'll want your symptom tree to look like this

Now wait for this pop up

Notice that my cure is at 92% and I have 256 DNA. I still haven't used any genetic shuffles and though I don't have to, I will just so I'm not watching that bar.

5.) Now, it's time to end to the world.
Evolve
Dysentery, Seizures, and Inflammation.

Be sure to devolve ANY other symptoms that evolve. We don't want some killer combo coming along and increasing lethality. We want the lethality to be relatively low.

Note : Spalin will likely be elected while waiting for the last pop up. When she threatens Russia, evolve Paralysis and you will unlock the Russian Nuclear Retaliation achievement. Paralysis has such low lethality that it will not effect the game. Sometimes her threat isn't until after you get the Plague in Space achievement, but why not kill two birds with one stone?

6.) FINALLY