Plague Inc. Nanovirus Speed Run Guide

blogger Nanovirus is the fastest of all plagues, faster than bioweapon, faster than virus and even faster than neurax worm. This is because in Nanovirus, there is the replication factory overload; coma, paralysis, Insominia and paranoia are free; insanity costs only 4 DNA and every trait costs 1 DNA less.


  • ATP Boost
  • Aquacyte
  • Symptostasis (absolutely necessary)
  • Mutation gene doesn't matter
  • Extremophile
Evolve Before Starting In China:
  • Insomina
  • Paranoia
  • Seizures
  • Insanity
  • Cysts
Then Evolve:
(If something not on this list mutated, devolve it.)
  • Hyper Sensitivity 
  • Paralysis
  • Coma 
  • Abcesses
  • Rash
  • Sweating
  • Skin Lesions
  • Coughing
  • Sneezing
  • Pneumonia
  • Nasuea
  • Vomiting
  • Diarhrea 
  • Pulmonary Oedema 
  • Pulmonary fibrosis 
  • Anaemia 
  • Hemophilia
  • Code Fragment interception
  • Code Segment Interception
  • Replication Factory Overload
  • Drug 1
  • Cold 1
  • Heat 1
  • Water 1
  • Water 2
  • Air 1
  • Necrosis
  • Dysentery 
  • Systemic infection
  • Drug 2
  • Drug immunity
  • Air 2
  • Extreme bioaerosol 
  • Bird 1
  • Bird 2
Once every country is infected:
If the replication factory overload ends, and not every country is fully or close to fully infected, quit and restart. Also if an island country closes its ports and isn't infected, quit and restart. 
  • Total Organ Failure
  • Hemoraghic Shock
  • Internal Hemorrhage
  • Immune Suppression
  • Tumours
  • All remaining Lethal Symptoms
This should result in 250 days or less on the Speed Run.

I hope this guide helped you :D


  1. This guide worked in around 208 days!

  2. Cnt even complete the run dude. Though i got 258 days after i changed a lil bit of the guide. Thanks anyways.

  3. 224 days, 5BH, worked for me.

  4. This guide is stricter than it needs to be... Still got less than 250 days and 5 biohazards though most countries including a few islands were not infected yet. It works better than it knows!

  5. 219 days! Works great. =] but it is not necessary to restart if the replication overload doesn't infect every country. I still had 3 islands to infect after the overload ended and got 219 days.

    There were two games right before this one where the overload only lasted for like one game-week, so I restarted those ones. Really don't know why it sometimes lasted quite awhile and sometimes stopped really quickly.