Plague Inc. Artificial Organ Scenario: Bacteria Brutal(3 Biohazards) Guide & Walkthrough

This guide will help you achieve a 3 gold biohazard score on Artificial Organ Scenario with the Bacteria plague. It is also possible to accomplish the task of getting 3 biohazards with different plagues.
(Click here for available plague guides for Artificial Organ Scenario)

Update: I recently found that a it is possible to get higher biohazards by finishing in mega-brutal difficulty. I'll post another guide on Bacteria in mega-brutal difficulty when I get the chance. As of now, this guide only works for brutal difficulty.

Achieving a 3 biohazard score on Bacteria is not that easy once you get a hang of how to correctly evolve transmissions, symptoms, and abilities. My strategy here is to spread the plague fast and start killing people as soon as the plague infects most of the world. Because this is a specific scenario, there is also a specific symptom we need to evolve in order to stop the manufacture of artificial organs. This guide is made for brutal difficulty, it may also work on inferior difficulties but I haven't tried that yet.

The key to defeating these artificial organs is to evolve the Insanity symptom. Doing so will make people rip out their organs which makes them die thus removing the problem of constant artificial organ manufacturing. I can keep going on how this happens, but I'll let you figure that out for yourself.

I wrote the guide by listing the order you'll need to evolve everything. Every evolution is listed one after the other so follow it. Without further ado, the guide:

Gene setup:
  • ATP Boost
  • Teracyte
  • Sympto-Stasis
  • Genetic Mimic
  • Extremophile
1.) Before selecting a country to start in, evolve these symptoms:
  • Coughing
  • Rash
2.) Start in China

3.) Continue to evolve the following symptoms:
  • Sneezing
  • Sweating
  • Skin Lesions
Reminder: From here until I tell you to stop, keep devolving any mutated symptom.

4.) Now transmissions, evolve the following:

  • Water and Air 1
  • Water and Air 2
  • Extreme Bio Aerosol
5.) Continue by evolving these abilities:
  • Drug Resistance 1 and 2
  • Cold and Heat Resistance 1
  • Cold and Heat Resistance 2
  • Environmental Hardening
6.) Now back to symptoms, evolve the following:
  • Necrosis
  • Insomnia
  • Paranoia
  • Seizures
  • Insanity
  • Cysts
  • Hyper Sensitivity
  • Paralysis
  • Coma
7.) Wait until you get the "No healthy person left" pop-up. After that appears, evolve these lethal symptoms as soon as you can:
Reminder: You can stop devolving mutated symptoms now.
  • Total Organ Failure
  • Hemorrhagic Shock
  • Internal Hemorrhaging
  • Systemic Infection
8.) Remaining DNA should be used to evolve Genetic Re-Shuffles. From here on, it won't be long until the entire artificial organ-ed world is eradicated

There you go, hope this guide has helped you achieve a 3 biohazard score on the Artificial Organs scenario. If you've got any tips and/or suggestions, share them with us by posting them at the comments. I'll try them out and include the good ones with this guide. Thanks and Happy spicy gaming!


  1. This strategy works great on both normal and brutal, I got three biohazards on each class the first try.

  2. I've never been able to evolve a symptom before choosing a country. There's no option to evolve your disease until you start.

  3. You have to use the instructions provided and then go to the disease screen.