Plague Inc. Artificial Organs Scenario: Bio-Weapon Mega-Brutal(3 Biohazard) Guide & Walkthrough

The Bio-Weapon plague type is one of the seven available plagues for use in order to complete the Artificial Organs Scenario. Don't want to use this plague to beat this scenario?

Click here for a list of available guides for other plagues.

As you may already know, the Bio-Weapon has a very amazing unique ability the greatly increases the lethality of the plague. It is best used when total world infection is achieved. In this strategy, we won't use it. Instead, we'll be letting the scenario's unique pop-up event combined with the bio-weapon's innate ability, the slow onset of lethality, to do the killing.

I've only used this strategy once, so don't put so much confidence in it being successful every single time. Although used only once, I'm a little bit confident that this strategy will work. You may say I rushed it, well I kinda did but it's better than nothing, right?

No more talk, let's begin.

Gene Setup:

  • ATP Boost
  • Aquacyte
  • Sympto-Stasis
  • Genetic Mimic
  • Extremophile

1.) Before selecting a country to start in, evolve the following:
  • Cysts
  • Abscesses
  • Coughing

2.) Start in China. Continue by evolving these symptoms in this exact order:
  • Hyper Sensitivity
  • Pneumonia
  • Coughing
  • Rash
  • Sweating
  • Skin Lesions
Devolve any symptoms that mutate. Do this only for a maximum of three times, don't bother devolving after the third mutation.

3.) Back to evolving stuff. Follow the order:
  • Water 1 & 2
  • Necrosis
  • Inflammation
  • Seizures
  • Drug Resistance 1 & 2
  • Insanity
During this step, two pop-ups will appear. The first one, saying "artificial organs saves lives" should appear shortly after evolving Necrosis. The second, saying "your plague is making people rip out their organs", appears right after evolving Insanity.

4.) Continue to evolve the following. Again, in this order:
  • Cold and Heat Resistance 1 & 2
  • Environmental Hardening
  • Air 1 & 2
  • Extreme Bioaerosol
  • Insect and Blood 1 & 2
  • Extreme Hematophagy
  • Paralysis
  • Coma

5.) Nothing to do at this point but wait for the world to end. Evolve whatever you want while waiting, I suggest lethal symptoms or Genetic Re-Shuffles. Prioritize whichever you prefer.

About doing this strategy only one time...I lied. I did twice, both games a win and both ended with those three sweet golden biohazards. I hope it did the same for you. Thanks for reading and HSG!


  1. The island countries (Greenland,Iceland,New Zealand,Etc.) shut down the land borders sometimes to quick. That being said...... Great guide!

    1. In my experience, Island countries will always be the hardest to infect in any mega-brutal game, especially in scenarios. Thanks for using this guide! Hope it worked well for you!

  2. Laurent Alphonse FerreiraMarch 18, 2015 at 1:38 PM

    I tried this way without succes (killed all infected patients), so instead upgrade Paralysis and Coma, I tried upgrade the remaining transmissions wwith 3 bio hazard at patch 1.9.