Plague Inc. Artificial Organs Scenario: Nano-Virus Mega-Brutal(3 Biohazard) Guide & Walkthrough

The Nano-Virus plague type is one of the seven available plagues that can be used in the Artificial Organs Scenario. If you want to finish this scenario with a different plague...

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If you don't already know, the Nano-Virus always starts with a cure being developed right away. It's unique abilities are all about slowing down the development of its cure. Symptom costs are reduced by a bit though, symptoms such as insomnia and coma that slow down the cure will cost nothing to evolve. I'd rate the difficulty of this plague in this scenario as a 6 on the scale of 1-10. Nothing's ever easy in mega-brutal difficulty - Why? Genetic Shifts. That's why.

In 2 games that I've played using this strategy, I always ended with a 3 biohazard score. It's quite a few games to say that this strategy always works. I wasn't able to take note of the scores I had with my games, but as a basis, getting a 3 biohazard score requires you to complete the eradication within 360 days and end with a cure completion below 60 or 50%.

Let's get on with the guide, first off, the gene setup:

  • ATP Boost
  • Aquacyte
  • Sympto-Stasis
  • Genetic Mimic
  • Extremophile

1.) Before selecting a country to start in, evolve the following symptoms:
  • Coughing
  • Sneezing
  • Insomnia
  • Paranoia
  • Cysts

2.) Start in China. Continue to evolve the following in this exact order:
  • Hyper Sensitivity
  • Paralysis
  • Coma
  • Abscesses
  • Rash
  • Sweating
  • Skin Lesions
Devolve any symptom that mutates. You'll only have to do this once.

3.) Continue to evolve the following in this order:
  • Water 1 & 2
  • Necrosis
  • Seizures
  • Code Fragment Interception
  • Code Segment Interception
  • Radical Elements Stabilised
  • Encryption Breached
  • Drug Resistance 1 & 2
  • Insanity
During this step, specifically after evolving Necrosis, the first pop-up should appear saying "Artificial Organs saves Lives. The second pop-up appear after evolving Insanity, you need to see the first one before this appears. You don't have to wait for them to appear, they'll show up eventually. Continue to the next step right after evolving Insanity.

4.) Once again, evolve the following in this order:
  • Cold and Heat Resistance 1 & 2
  • Environmental Hardening
  • Air 1 & 2
  • Extreme Bioaerosol
  • Replication Factory Overload
  • Genetic Hardening 1 & 2
  • Genetic Re-Shuffle 1, 2, and 3

5.) From here onward you'll just have to watch people get infected and die. The second pop-up that makes people rip out their artificial organs increases your Nano-Virus' lethality at a steady rate. That itself is enough to kill people fast. If you want a better highscore, wait for the pop-up that says your plague is about to eradicate humanity. After the pop-up's appearance evolve Broadcast Interceptor Overload right away.

Remaining DNA you may have is best used to evolve very lethal symptoms such as Total Organ Failure, Hemorrhagic Shock, etc. The best time to evolve all these is when you completely infect the entire world. 

That about does it. I hope this guide has helped you achieve those 3 golden Biohazards. Thanks for reading this guide and HSG!


  1. Easiest one to get 3 Biohazards (Mega-Brutal). The Replication Factory Overload ability helps a lot in Mega-Brutal. Even easier than prion.

  2. Great Guide! Thanks!

  3. Are you going to make a guide about all the scenarios? (3 Biohazard and Mega Brutal)

    1. That's the plan. I'm currently working on Nipah Virus. Already got 3 bio on mega-brutal, but strategy still needs work.

  4. Is the gene setup important?

    1. I don't think it's that important, although it will make things far more easier.

  5. Thanks for the guide. Failed 5 times following this the 6 times finally got it. I found toward the end of the game I always have 1 or 2 countries that closed all its borders.

    the solution I found for this is that toward the end of the game, develope nausea--> vomit --> diarrhea symptoms helps. I also evolved blood and insect 1 for the sake of those left over countreis.

  6. I'd like to announce, this nanovirus-strategy is somewhat killer! I play on Plague Inc. evolved, and this is like a damn cheat! I did this on artificial organs, volcanic ash and xenophobia scenario, all on megabrutal, and every game was successful on first try. Of course i always evolved as soon as i had the DNA, dont wanna miss a single day in infectivity. ^^ but THANKS DEAR SPICY! This is the best stradegy i've ever seen on plague inc...