Plague Inc. Unknown Origin: Nano-Virus Mega-Brutal(3 Biohazard) Guide

For a list of available plague guides for the Unknown Origin Scenario, Click here.

Nano-Virus always starts with the cure already being at the development stage, although it hasn't been really detected yet. The good thing about this plague type is that symptoms are much more cheaper than other plague types--cure-slowing symptoms even cost nothing to evolve.

What you really have to watch out for while playing Nano-Virus is the cure progression. It might seem a little slow at start, but as soon as the plague gets detected it'll take mere months for the cure to be completed. That being said, always take full advantage of cure-slowing symptoms and abilities, especially Nano-Virus' unique abilities.

Strategies posted here will also work for a normal non-scenario game of Nano-Virus. The Unknown Origin scenario, simply put, will only choose your starting country for you, thus making it seem like just like any other normal game.

Spicy's Strategy

I have tested this strategy a number of times in a normal game of Nano-Virus in mega-brutal difficulty. While having India as the origin country, the best final stats I had were finishing within 290 days with a cure completion of 26%.

Although I had no luck in having India as my starting country in the scenario itself, I've found that this strategy would also work for the following countries(I've included screenshots of the final stats I had):
  • India - This is a screenshot of the stats of a normal game I had while testing the strategy
    Normal Game stats: Strategy Testing Phase
  • Angola
    Angola: Final Stats
  • Brazil
    Brazil: Final Stats
  • Indonesia
    Indonesia: Final Stats

I have not made any changes to strategy for each country. I stuck with the strategy and evolution order all through-out each game.

Recommended Gene Setup:

  • ATP Boost - Having this gene will help tremendously since we are able to evolve some symptoms at the earliest part of the game.
  • Aquacyte - Island countries will always be a pain to infect. This gene will boost ship transmissions to help out with those pesky island countries.
  • Sympto-Stasis - Nano-Virus already has cheap symptoms, and having this gene will make it stay cheap and prevent the 1 DNA increase on every symptom evolved.
  • Genetic Mimic - You start with the cure already being developed. The least we could do is to slow it down.
  • Extremophile - You'll never know which country you'll be started in, having this gene will give a small boost to infection rates.

Let's Get Started

1.) Wait for your pre-selected country. If you're using this guide for a normal game, select India as your starting country. Obviously, you'd want to start in India--or the ones I've listed above that were successfully finished.

2.) Immediately after popping the first red bubble, evolve the following symptoms in this order:
  • Coughing
  • Rash
  • Insomnia
  • Paranoia 
  • Cysts
  • Hyper Sensitivity
  • Paralysis 
  • Coma
  • Abscesses
  • Sneezing
  • Sweating
  • Skin Lesions
  • Seizures
  • Insanity

3.) Some of the symptoms above will cost 0 DNA to evolve. At this point, If any lethal symptom mutates devolve them immediately. Continue by evolving the following in this order:
  • Code Fragment Interception
  • Code Segment Interception
  • Water 1
  • Air 1
  • Water 2
  • Bird 1
  • Radical Elements Stabilised
  • Air 2
  • Extreme Bioaerosol

4.) Do not be too alarmed by the rapid progression of the cure, this strategy was built in a way that the cure would never reach more than 90%. Again, continue by evolving the following in this order:
  • Cold Resistance 1
  • Drug Resistance 1
  • Cold Resistance 2
  • Necrosis
  • Drug Resistance 2
  • Encryption Breached
  • Dysentery
  • Diarrhoea
  • Pulmonary Oedema
  • Pneumonia
  • Genetic Hardening 1 & 2

5.) At this stage of the game, we'll have to wait until every country is infected. Check your infection spread summary(World-Data) to check if every country is infected. Once every country has been infected, evolve Replication Factory Overload.

Wait for a pop-up of either the end of the replication overload or the complete infection of the world(No one healthy pop-up)--Usually, replication overload ends first. After one of those two things happen, evolve the following:
  • Total Organ Failure
  • Hemorrhagic Shock
  • Internal Haemorrhaging
  • Tumours
  • Systemic Infection
  • Genetic Re-Shuffle 1, 2, and 3

6.) People should be dying off quickly now. Right before the complete eradication of humanity, a pop-up usually shows up saying "[plague name] about to eradicate humanity". After seeing this pop-up, immediately evolve Broadcast Interceptor Overload to take a bit off the current cure progression.

That's it. I hope this guide has helped you get those 3 golden biohazards for the Nano-Virus in the Unknown Origin Scenario. Thanks for reading this guide.

If you guys have any tips or other strategies you'd like to share, post them at the comments below or send them directly to us via our submit section. HSG!

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