Plague Inc.[Submitted Guide] Prion Speed Run Guide

This guide has been written and submitted by zephski01. Submit your own guide to us now via our submit section!

Spicy's Comments: Pretty simple and straight-to-the-point guide. Remember to comment and give some feedback for the guide's improvement!

Gene set up:
  • ATP boost
  • Aquacyte
  • Sympto-stasis
  • Base Hydrolysis
  • Extremophile

1. Evolve rash and sweating

2. Start in India

3.evolve in this order
  • Skin lesions
  • Coughing
  • Sneezing
  • Cysts
  • Hyper sensitivity
  • Abscesses
  • Pneumonia
  • Aneimia
  • Haemophillia
  • Nausia
  • Vomiting

4. Evolve water and air 1 and 2

5. evolve abilities
  • Cold and drug resistance 1 and 2

  • Livestock 1 and 2 and extreme bioarosole

7. Evolve diarrhoea and necrosis

8. Wait till all countries half infected then evolve all fatal symptoms

9. If done right you finish at about 300 days

You get five biohazard scores


  1. Super easy guide to follow. Finished in 277 days!

  2. 340 :( how you get 260 days

  3. Not even close to working anymore. Not sure if they changed infectivity in an update or something. Tired several times and majorly failed.

  4. I managed to get 5 Biohazards but haven't had a chance to repeatedly test/refine it yet. I used Metabolic Jump, Teracyte, Sympto-Stasis, Base Oxidisation, Extremophile, and started in China. I first evolved nausea, then coughing, vomiting, then rats, water, sneezing, and I have to run through it again because I was on auto-pilot after trying it so many times. Hope this helps someone.

  5. I'm with April! This doesn't work. I have tried 2 dozen times following it to a T and maybe a dozen more changing it slightly here and there and my record is 386 days. Need a new guide.