Plague Inc. Bio-Weapon Brutal Guide / Walkthrough

The Bio-Weapon plague type is the 7th and final unlock-able basic plague type in Ndemic Creations' game, Plague Inc. It is unlocked by finishing Nano-Virus in either Normal or Brutal Difficulty(Nano-Virus Guide for Brutal here).

The Bio-Weapon has four unique abilities, three of which are able to stem into two more abilities that are needed to be evolved in order to unlock the fourth one. These three abilities are Gene Compression, Deactivated Modified Genes, and Nucleic Acid Neutralisation. After evolving every available evolution of these abilities, you will be able to unlock the fourth ability which is Unlock Annihilate Gene. This ability is amazing as it maxes out your plagues lethality, making every infected person drop like flies.
The key strategy for my guide is obviously the Bio-Weapon's fourth ability, Unlock Annihilate Gene. The moment this ability gets evolved people will die so quickly they won't even be able to get the cure completion to 5%.

Some of you might have had a hard time when you first tried using the Bio-Weapon plague type. This plague type gets more and more lethal as time passes by. You may even find yourself killing people faster than infecting them. Bio-Weapon's other three abilities help contain its lethal nature. Gene Compression delays the increase of lethality, Deactivated Modified Genes reduces the lethality, and Nucleic Acid Neutralisation resets the lethality to 0 but over time it regenerates back.

If you follow this guide I have right here, your virtual countries won't even know what hit them.

By this time I think it's safe to assume that you have unlocked every available gene. We'll make good use of these in my guide to make short work of virtual earth.

First things first the gene setup:
ATP Boost
Genetic Mimic

After setting up your genes, we begin.

1.) Before Selecting a country to start in, evolve the following:

  • Coughing
  • Gene Compression 1 and 2
2.) Start in India

3.) Evolve the following as soon as you have the DNA to do so:
  • Water and Air 1
  • Gene Compression 3
  • Deactivated Modified Genes 1
  • Water and Air 2
4.) Be sure to devolve any mutated symptom that appears to make sure no country detects your plague.

5.) While evolving the next set of Transmissions and Abilities, If your Bio-Weapon starts to kill people evolve Deactivated Modified Genes 2 right away.
  • Extreme Bioaerosol
  • Cold and Drug Resistance 1
  • Cold and Drug Resistance 2
6.) Now we wait for everyone to get infected by our Bio-Weapon. If at some point your plague starts killing people again evolve Deactivated Modified Genes 3 immediately. In the rare chance that it starts killing again before you infect the entire world evolve all these at once, if you can:
  • Nucleic Acid Neutralisation 1, 2, and 3
  • If, once again, it starts to kill people just let it be. You're going to need these three abilities in order to unlock the key ability we need anyway.
7.) After awhile you should get a pop-up saying something like "no one in the world is healthy". As soon as you see this evolve Unlock Annihilate Gene. If you can't see this ability yet, remember that you need to evolve every stem of Gene Compression, Nucleic Acid Neutralisation, and Deactivated Modified Genes.

8.) Evolving the Annihilate Gene maxes out the Bio-Weapon's lethality, making it kill people super fast. Now, allocate your remaining DNA evolving the following:
  • Genetic Hardening 1 and 2
  • Insomnia
  • Paranoia
  • Seizures
  • Insanity
  • Inflammation
  • Paralysis
  • Coma
9.) At this point, you just have to sit back and watch your Bio-Weapon destroy humanity. You can opt to evolve some Genetic Re-Shuffles to lower to cure progress if you want to.

That does it, congratulations on finishing Bio-Weapon in brutal difficulty! Here are my stats on my 2 latest games doing this strategy.
1st game - 549 days| 3% Cure Completion| 5/5 Biohazard
2nd game - 598 days| 3% Cure Completion| 5/5 Biohazard

If you guys have any better strategies or some tips you'd like to share. Post them at the comments below, I'll be sure to include the good ones along with this guide. Happy gaming!


  1. Great Guide!, here are my winning stats
    1st game, 595 days | 2% Cure Completion | 5/5 Biohazard

  2. It took me 2 times but I got it. Thanks

  3. ...eeeeh, I dunno about you, but a lot of times, whenever I used the Gene Compression, it didn't affect my plague's lethality AT ALL (it wasn't much to begin with, but it was still killing off a LOT of people)...and Nucleic Acid Neutralization has NEVER done ANYTHING towards stopping the death toll; its only because I went completely for broke and started evolving every transmission I could (and then Annihilation Gene; I got my transmissibility rate up to a certain point, and the Gene boosted it to 100%) that I managed to win-- and STILL I got 57% cure rate. I don't mean to sound like an ass, and maybe its just because I really suck, but I NEVER, on any of these strategies (on Brutal or above) managed to make it with 5-15% cure rate. Don't get me wrong, they ARE successful and help me win, it just makes me wonder what I am doing wrong when so many are reporting the same results as the person who wrote this. Maybe my game's glitchy? Maybe I just am a screwup at this game (TOTALLY possible, given how many times I had to lose before I actually managed to win.)

  4. I found this worked for me on Mega-Brutal too, and I got less than 20% cure completion. The only slight differences for me was that I evolved gene compression etc. up to lvl. 3 as quickly as I could and just left them there, and once I evolved all the above things I let things evolve as they would to increase infection and everything. But, once I got everyone infected I unlocked the annihilation gene and pulmonary fibrosis, total organ failure evolved by itself and everyone dropped like flies.

  5. How did you unlock Patho-Stasis? I beat every other type on Casual, and Brutal, however i didnt get it.

  6. 1st game, 477 days, 11% crure completion , 4/5 biohazard , score 66650
    Same strategy but i used genetic re-shuffles 1,2

  7. Flavia Auditore da FirenzeAugust 7, 2014 at 11:22 PM

    592 days, 5% cure completion, score 167000, 5/5 Biohazard on Brutal. Works like a dream.
    My Bio-Weapon never get to kill anyone before Unlock Armageddon Gene (lucky, I guess?)

  8. Flavia Auditore da FirenzeAugust 7, 2014 at 11:22 PM

    Just play enough times and you'll unlock all the genes, one at a time.

  9. 636 days on Mega brutal 29% cure (reduced from a high of 50%) 5/5

  10. Worked perfect! Thanks!

  11. Dang!
    559 days
    6% complete

  12. And 5/5 biohazard signs!

  13. Holy Crap!
    1st game
    569 Days
    3% Complete
    291,880 score
    And 5 of 5 Biohazards.

  14. I tried 2 times in a row and before the whole world was infected the cure was done I even tried all 3 reshuffles and all hardenings but I still lost ): how do you guys get 2% cure???