Yo It's Spicy: Plague Inc: Simian Flu Mega-Brutal Guide & Walkthrough

Simian Flu Mega-Brutal Guide

It is finally here folks! It took many hours to make this guide and is by far the hardest guide I have ever done. That being said I managed to do it and found a great strategy that uses the simian flu gene Together Strong that increases the total number of DNA points that apes colonies generate. Do not be shocked if this guide takes over 1000 days as the simian flu plague type is by far the slowest plague type in the game. I still love the ability to generate DNA points by Ape Colonies. It is actually pretty easy once you find out that ape colonies provide possibly unlimited DNA points to my knowledge. In one game before they even set up one cure lab I already had over 400 DNA points! So the hardest part is using the ape colonies ability in a good way. It is to note as well that this is the first plague type in Plague Inc. made off a movie. It may require tweaking as this Plague Type has many different factors that our not set in stone so I would tweak it if for some reason the late-game (22. and over) doesn't work! It is depends on the game so I can really not make a good strategy for the end of the game. It will however work in a typical game and it is up to you mostly to finish it. The bad part is the Simian Flu depends so much on variables that making a set-guide for the end of the game would be impossible. I did the best I can on the end-game but it is up to you how you want to evolve your plague past then. Hope this guide helps you!

Note For Fans Playing on Plague Inc. Evolved: This guide was made for the original Plague Inc. and POSSIBLY may not work for Plague Inc: Evolved. No support will be provided for Plague Inc: Evolved! If this strategy does not work on Plague Inc: Evolved please do not downvote this page as it will make us think something is wrong with our current guide! Please comment down below so we can make this guide even better! I possibly may get Plague Inc: Evolved but at this time there is going to be no support!

Tips

Use the special ability Ape Rampage if a Gen-Sys lab is set up. I did not include to destory the Gen-Sys labs directly in the guide due to the fact that they may pop-up at any given location on the map.

If drones start attacking your ape colonies simply use the special ability travel to move them to different locations

Mutation Guide

Devolve these symptoms! When I say stop following this guide it is okay for these symptoms to evolve.
- Neuro-Enhancement I, II, and III, and Total Brain Death
- Pulmonary Haemorrhage
- Haemorrhagic Shock
- Hypocoagulability
- Internal Haemorrhaging
- Hydrocephalus
- Meningitis
- Coma
- Dysentery
- Gastric Ulceration
Note: Neuro-Enhancement 1,2, and 3 should not be allowed to mutate even when the mutation guide says to end unless the guide says so.

Gene Setup (Required)

Metabolic Jump
Aquacyte
Ion Surge
Together Strong
Extremophile

If you did not happen to unlock all of the "simian flu" genes that are required to use this strategy click here.

If you did not happen to unlock all of the "regular" genes that are required to use this strategy click here. (Note Coming Soon!)

START FOLLOWING MUTATION GUIDE NOW!

1.) Start in Central Africa

2.) We are going to make the apes smart early due to the fact that it allows us to get a ton of DNA points early and remain somewhat undetected for a reasonable period of time.

Simian Neuro-Genesis- In Ability Section

3.) Believe it or not we want to keep infectivity low early on to give us time to get extra DNA points from colonies. You will eventually have to devolve joint pain but not until later if rash or headache evolves. If headache or rash doesn't evolve don't evolve joint pain.

(If Headache or Rash Evolves) - In Symptom Section
Joint Pain -In Symptom Section

4.) At this point it is time we evolve ape colonies and make one soon in Central Africa.

Ape Colonies - In Ability Section

5.) At this point as soon as possible make an ape colony in Central Africa.

(At this point as soon as possible make an ape colony in Central Africa)

6.) At this point we want our apes to become intelligent across the globe so we are evolving these two ape transmissions as a good base infectivity.

Inter-Genus Dissemination I - In Transmission Section
Inter-Genus Dissemination II - In Transmission Section

7.) We are now evolving symptoms that increase base DNA point gains for ape colonies.

Cognitive Shift - In Abilities Section
Education - In Abilities Section

8.) At this point we are going to make an ape colony in East Africa. Then West Africa.

(At this point as soon as possible make an ape colony in East Africa)
(At this point as soon as possible make an ape colony in West Africa)

9.) We are now going to evolve all of the ape transmissions to keep spreading the infection.

Sebaceous Excertion - In Transmission Section
Blood Gift - In Transmission Section
Cutaneous Transfer - In Transmission Section
Submissive Conception - In Transmission Section
Excrement - In Transmission Section

10.) Now we are going to make two more ape colonies to generate even more DNA points.

(At this point as soon as possible make an ape colony in Sudan)
(At this point as soon as possible make an ape colony in Angola)

11.) Now we are going to evolve these abilities to keep people from noticing the newly intelligent apes and gives them more time to generate DNA points.

Primal Awareness - In Abilities Section
War Paint - In Abilities Section
Covert Expertise - In Abilities Section

12.) We are going to evolve these abilities now to prevent genetic shifts from making them more expensive.

Drug Resistance I - In Abilities Section
Cold Resistance I - In Abilities Section
Genetic Hardening I- In Abilities Section

13.) We are going to do this to transport apes to different islands.

Organized Travel - In Abilities Section
Logistics - In Abilities Section
Seafaring - In Abilities Section

14.) Note skip this step if any one of the Americas are infected.

Use the travel special ability on Morocco and drag it to Brazil if the Americas are not infected at all.

15.) Again we are going to evolve Ape Rampage to prevent the cost from going up because of genetic shifts.

Ape Rampage - In Abilities Section

16.) Now we are going to evolve these

Cold Resistance II - In Abilities Section
Drug Resistance II- In Abilitiies Section

17.) Now we are going to build a colony in Egypt.

(At this point build a colony in Egypt)

18.) We are going to buy this to slow down cure progress.

Genetic Hardening II - In Ability Section

19.) Wait and collect DNA points until the following message pops-up.

New Gen-Sys lab in <Country Name> working on cure
Gen-Sys is setting up a new lab to work on the cure for <Disease name>. To remain active, it will need regular shipments of apes to experiment on as trauma rates are 'high'.

20.) Now it is time to infect the world. Note that when Hominidae Bridge is evolved bubbles are going to pop-up fast so slow down or pause the game.

Hominidae Bridge - In Symptoms Section
Now Devolve Joint Pain (Keep Doing This Until It Costs Over 10 DNA Points to Devolve) I would like to note that it almost never gets that far. - In Symptoms Section
Air I - In Transmissions Section
Air II - In Transmissions Section
Water I - In Transmissions Section
Water II - In Transmissions Section
Extreme Bioaerosol - In Transmissions Section

21.) Evolve the following to allow apes better combat skills.

Primal Hunt - In Abilities Section

22.) Now evolve these symptoms to decrease research and cure speed.

Photophobia - In Symptoms Section
Subconjunctional Bleed - In Symptoms Section
Subconjuctional Haemorrhage - In Symptoms Section
Blindness - In Symptoms Section

23.) Evolve Blood I and Blood II if not all humans are infected. If the ports are shut-down do not evolve the symptoms but simply drag the apes to the countries. Also stop following the mutation guide!

STOP FOLLOWING MUTATION GUIDE NOW!

At this point it gets very variable. So this is just recommendations.

Blood I - In Transmission Section
Blood II - In Transmission Section
Extreme Haemoaerosol- In Transmission Section (Pick If You Want Too Get This Or Not)
Drag Apes Into Non-Infected Countries

Please note that you should not use countries that have ape colonies in them and drag them into uninfected countries.

24.) Wait until all countries are infected/Cure Progress is over 10%. This is important. Now it is time for a Planet of the Apes.

Neuro-Enhancement I - In Symptoms Section
Neuro-Enhancement II - In Symptoms Section
Neuro-Enhancement III - In Symptoms Section
Total Brain Death - In Symptoms Section
Haemorrhagic Shock - In Symptoms Section
Internal Haemorrhaging- In Symptoms Section
Meningitis- In Symptoms Section

25.) You win!

It should be noted AGAIN that this is by far the longest plague to beat on mega-brutal so patience is key. Also I would recommend you go see Dawn of the Planet of the Apes! Saw it yesterday and it was amazing! The special effects and the story in my opinion were the best parts. Any who, this should work on Mega-Brutal! Have fun!