Plague Inc. Artificial Organs Scenario: Fungus Mega-Brutal(3 Biohazard) Guide & Walkthrough

The Fungus plague is one of the seven available plagues types available for use in the Artificial Organs Scenario. This guide was made specifically for Mega-Brutal difficulty. If you want to use another plague to beat the Artificial Organs scenario.
Here's a link to the guides I've made for this scenario.

Beating a plague in mega-brutal difficulty isn't an easy thing to do, and this scenario makes it just a bit harder. In this scenario, the world is able to quickly replace any damage organs. What this means for us is that our plague's lethality will be significantly reduced when the world starts replacing organs. This is easily countered by the evolution of the Insanity symptom that makes people rip the organs right out of their bodies. Because of the Fungus' inability to transmit through long distances, we'll have to make full use of its Spore Burst ability. Read on further for a little more background on my strategy.

One thing you have to remember while playing in this scenario, you can't just go evolving lethal symptoms when you are prompted that organ replacements are being made. You'll just be wasting your time because your plague's lethality will be lowered so much it's like you're not even killing anyone at all. In my experience with this scenario, you will have to wait until specific pop-ups show up before even thinking of evolving deadly symptoms.

Here's a couple of things you should know about regarding your success of achieving a 3 biohazard score in this scenario with this guide:

  1. You want the pop-ups to show themselves as soon as possible. You can't really control when they'd show but you need to wait for them at certain points before proceeding to the next steps.
  2. Infecting island countries will be a pain in the ass. Obviously, you'll want to infect these countries with your spore bursts but that doesn't always happens so your stuck with waiting for ships to infect them.
  3. In order to get a 3 biohazard score, you'll need to finish killing people within 365 days. Speed in infecting and killing are the key to beat this plague within a year. This also explains why you want #1 to happen quickly.
  4. Genetic Shifts. These random unseen events increase DNA costs and are one of the primary reasons of failure.
  5. Be very careful on evolving Spore Bursts and Eruptions at the same time. You might be unable to pop every red bubble unless you have super fast reflexes. DNA in mega-brutal difficulty is very important because #4
I think I've covered everything, now onto the guide. First, the gene setup:
  • ATP Boost
  • Aquacyte
  • Patho-Stasis
  • Genetic Mimic
  • Extremophile
1.) Before selecting a country to start in, evolve the following:
  • Rash
  • Sweating
  • Spore Burst

2.) Start in China, then continue to evolve Spore Burst all the way around until you get to evolve Spore Eruption, evolve this as well.

3.) Continue evolving the following symptoms:
  • Skin Lesions
  • Cysts
  • Hyper Sensitivity
  • Inflammation
  • Seizures
Reminder: Devolve any mutated symptoms until I tell you to stop.

4.) Evolve Water 1 and 2 Transmission then wait until this pop-up shows up. 
Artificial Organs to save lives
5.) After seeing the prompt mentioned above, continue by evolving the next set of Spore Bursts and one Spore Eruption all the way until you get to evolve Spore Hardening. Needless to say, evolve that as well

6.) Now evolve the following abilities in this order:

  • Drug Resistance 1 and 2
  • Cold and Heat Resistance 1
  • Cold and Heat Resistance 2
  • Environmental Hardening

7.) At this point, you'll need to wait until every country is infected. To check, go to World-Data-Infection Spread Summary. 
Once every country is infected, evolve Insanity symptom right away. After a short time, a pop-up should appear. You need to see this prompt before continuing on to the next step.
Victims of [Plague Name] rip out organs
8.) Right after seeing the pop-up above, evolve the final set of symptoms:
  • Necrosis
  • Hemorrhagic Shock
  • Coma
  • Total Organ Failure
9.) Extra DNA you get should be used to evolve Genetic Reshuffles. There's also a chance you'll be unable to evolve Total Organ Failure because of Genetic Shifts. If you get a prompt saying "Your plague is about to eradicate humanity", instead of waiting to evolve the final symptom it'd be better to evolve Genetic Re-Shuffles.

Now just wait for humanity to be erased off the face of the earth. If you've managed to finish within 365 days, Congratulations! If not, just try again. You are bound to win after a few tries.

I hope this guide has helped you get a 3 biohazard score in the Artificial Organs Scenario. If you've got any questions, tips, or strategies you'd like to share, post them at the comments below. I'll include the good ones along with this guide. Thanks for reading my guide and Happy Spicy Gaming!


  1. This strategy works wonderfully! I beat it in mega-brutal with two biohazards (over 365 days), and then beat it on casual for three biohazards and the achievement. ^=^

  2. I've repeated this particular strategy 2 days straight without a single Mega Brutal 3 star win. I've gotten close with some variations. Hit me up on Steam as I'm definitely following it step by step and wonder if something is missing.

  3. I believe that this scenario is quite different in Plague Inc. Evolved. Played with the strategy and got 3 biohazards in 3 out 5 games, today.

    Some luck is needed, I think. Since the country infection order really affects how successful the strategy is going to be.

  4. on my 15th tried. Still unlucky getting New Zealand or Iceland border got shot down before successfully spread plague to there...