Plague Inc. Scenario: Frozen Virus Mega-Brutal (3 Biohazard) Guide & Walkthrough

The Frozen Virus scenario is one of the recently released scenarios included in the April 24, 2014 update. As the in-game description says, it is a virus that was frozen and preserved in permafrost for over 30,000 years and was recently thawed by scientists, one of which is patient zero. Because it was preserved for such a long time in permafrost, the virus has lost some of its abilities. The main objective in this scenario is to, as with all plagues, eradicate humanity.

In this scenario, you'll control a plague which has its own unique set of abilities, transmissions, and symptoms. As abilities go, you will notice that you get to evolve DNA Repairs. What this does is unlock, or recover, the DNA sequence of the recently thawed Virus. This scenario also has a fixed starting country which is Russia. You'll quickly realized, upon trying out this scenario, that achieving a 3 biohazard score will be no easy task. Read on to the rest of my guide and you shall get just that.

To get a 3 biohazard score in mega-difficulty, we will have to destroy humanity in less than 365 days. Any longer than that time frame and we won't be able to get those 3 golden biohazards. We will have to infect as fast as possible and evolve the right symptoms in order to finish quickly. Like the Neurax Worm's Transcendence symptom, the Frozen Virus has a specific symptom that removes the need to kill people, the Neanderthal Regression symptom. The only thing we'll have to worry about is infecting them fast and gaining a whole lot of DNA.

Before I continue on with the guide, there's some things that you should know about first.

1. If at the start of the game you get a prompt or pop-up saying that ships have been sterilized, restart the game. DNA is very precious in this scenario and spending them on water transmissions will waste both time and DNA.
2. We'll be heavily relying on symptom mutations. This is because getting the key symptom to finishing this scenario requires a whole lot of DNA. Add the fact that we are attempting this in mega-brutal difficulty with its Genetic Shifts, the cost of evolving the key symptom would be unimaginably costly.
3. Evolve as soon as possible. By this I mean, memorize the cost of your next evolution and once you get the needed DNA evolve it right away. Do not hoard DNA points, it's really not recommended.
4. Your success in the end is determined by mutations and Genetic Shifts. If you manage to get lucky and mutate the needed symptoms, good for you. If you're lucky enough to not get insane Genetic Shift increases, good. If it turns sour though like not having the mutations needed and getting insane increases on shifts, then just try again.
5. As you're about to finish, there are times when the cure progression gets too high, maybe even at 98%. Don't worry about that if you think you're close enough to getting the final symptom. I once had a game where the Cure completion reached 100% then I managed to mutate the last symptom. I won the game and had a 3 biohazard score.
6. If you fail, try again. This is the best strategy I have at the moment and it works, for me, most of the time.

That about covers the warnings, I think. Now onto the guide. First, the gene setup:

• ATP Boost
• Aquacyte
• Patho-Stasis
• Darwinist
• Extremophile

1.) The Virus starts at Russia, after the introductions immediately evolve these symptom and ability:

• DNA Repair 1
• Edentulism

2.) Continue to evolve the following transmissions in this order as soon as you have the DNA:

• Amoeba 2
• Livestock, Bird, and Insect 1
• Amoeba 3
• Livestock, Bird, and Insect 2

3.) Now onto abilities, evolve them in this order:

• DNA Repair 2, 3, 4, and 5
• Full DNA Repair
• Drug Resistance 1 and 2
• Heat Resistance 1, 2, and 3

4.) Wait until your cure progression reaches 50%. Why do this? Because we want to save DNA and let the Virus mutate some symptoms, if you're lucky enough to mutate the ones listed here, you'll save a lot of DNA.

Evolve these symptom if they aren't mutated yet.

• Carnivorous Denticulation
• Bone Dysplasia
• Cranial Elephantitis
• Neanderthal Regression

These symptoms will costs a lot of DNA. A lot. So, if you're lucky enough to mutate 2 or 3 of them, congratulations. 

After evolving Neanderthal Regression, once everyone is infected you'll be prompted by a pop-up saying that humanity has regressed to its neanderthal state and you'll be brought to the victory screen. If you've manage to finish within 365 days, 3 golden biohazards are awarded to you.

I hope this guide has helped you achieve a 3 biohazard score on the Frozen Virus scenario. Like I said before the guide, there are a lot of factors that affect your success rate but after a few tries you'll always get a win.

If you've got any questions, tips, and strategies you'd like to share, post them at the comments below. I'll include the good ones along with this guide. Knowing this guide is not that perfect yet, I'll entertain any questions you might have to the best of my abilities. Thanks for reading my guide and Happy Spicy Gaming!