Plague Inc. Unknown Origin: Prion Mega-Brutal(3 Biohazard) Guide

For a list of available plague type guides for the Unknown Origin scenario, click here.

In my opinion, Prion is pretty much just like Bacteria and Parasite so I used the same strategy I used for the previous plagues. Prion's unique abilities lets it slow down the cure, like the Genetic Hardening ability, but these abilities would seem to be really unnecessary if you're aiming for 3 biohazards on mega-brutal difficulty. Why? Because DNA is better put towards infectivity in the early stages and towards lethality on the mid to the late stages of the game.

Guides and strategies posted here can also be used on a normal non-scenario game of Prion. Since the Unknown Origin scenario just randomizes your starting country and doesn't really affect overall game play besides that fact. As with other guides I've made, my suggested countries are India and China.

Spicy's Strategy

As I've stated above, I'll be using the same strategy I used for Bacteria and Parasite. I've made no significant changes to the strategy. Before actually using this strategy for the Unknown Origin scenario, I've tested it over and over again on a normal game of Prion in mega-brutal difficulty. I always finished within 370 days with a cure completion of below 18%.

The ideal country to start in is India, but this strategy for Prion has also worked when started at Iran and Saudi Arabia--I have yet to test other countries.

Here are some screenshots of the final stats of each game I had using this strategy:
  • India - These stats are from a normal game when I was testing this strategy. I failed to take a screenshot of the successful game I had while playing the scenario.
    Strategy Testing on a normal non-scenario game.
  • Iran - exceeded 365 days, but was still able to get 3 biohazards. Took longer than expected because of the late infection of Greenland and New Zealand
    Final stats - Iran
  • Saudi Arabia - Strategy worked extremely well without needing any changes to the evolution order.
    Final stats - Saudi Arabia

Although this strategy has already worked extremely well for me, I still recommend you to experiment with it to get a better score.

Gene Setup:

  • ATP Boost
  • Aquacyte
  • Sympto-Stasis
  • Genetic Mimic
  • Extremophile

1.) If you are using this strategy for a normal game of Prion, select India as your starting country. Wait for your random country to be selected. You will want to start at either India, Saudi Arabia, or Iran-India being the most suggested of the three. If you are started on a rich country, it's better to just restart.

2.) Pop the very first red bubble then evolve the following in this order:
  • Nausea
  • Cysts
  • Rash
  • Abscesses
  • Coughing
  • Sneezing
  • Sweating
  • Skin Lesions
  • Pneumonia
  • Pulmonary Oedema
  • Diarrhoea

3.) Devolve any mutated symptom that appears, but only do this for a maximum of three times--the first two will give you much needed DNA while the third one costs nothing, succeeding ones will cost DNA though. Continue by evolving the following:
  • Water 1 & 2
  • Blood 1 & 2
  • Cold Resistance 1
  • Drug Resistance 1
  • Cold Resistance 2
  • Necrosis
  • Drug Resistance 2
  • Vomiting
  • Hyper Sensitivity
  • Pulmonary Fibrosis
  • Dysentery
  • Insomnia
  • Paranoia
  • Seizures
  • Insanity
  • Paralysis
  • Coma

4.) At this point, wait until the world is completely infected(A pop-up will appear). If you don't want to wait for the pop-up, keep an eye on your last infected country and when the infected count reaches 50% continue. As soon as the pop-up appears(or your last infected country reaches 50% infection), evolve the following:
  • Total Organ Failure
  • Hemorrhagic Shock
  • Internal Haemorrhaging
  • Tumours
  • Systemic Infection
  • Inflammation
  • Fever
  • Immune Suppression

5.) The last three symptoms are optional, I only included them to max out the lethality as much as possible. Remaining DNA is best put towards the evolution of Genetic Re-Shuffles. Prion's unique abilities do not lessen the current cure progression, if you're wondering.

After all that evolving, all you need to do now is to watch humanity get erased by a Prion plague. Thanks for reading this guide and I hope it has helped you get those 3 golden biohazards for the Unknown Origin scenario.

If you have any tips or strategies you'd like to share, post them at the comments below or send them to directly to us via or submit section. We'll include the best tips and guides along with this guide to further its improvement. HSG!

1 comment :

  1. Southeast Asia for the win! I think as long as you get a poor country and can get either China or India quickly this strategy will work.