Plague Inc. Unknown Origin: Fungus Mega-Brutal(3 Biohazard) Guide

For a list of available plague guides for the Unknown Origin scenario, Click here.

Once again, I am back to a plague type that I don't really feel comfortable playing in, Fungus. To be honest, I'd rather play scenarios like Black Death over and over again than play 10 games of Fungus. I don't really hate this plague type, but the randomness of spore bursts and the fact that this plague type has a hard time infecting through ships and planes makes everything harder than it already is at mega-brutal difficulty.

One advantage it has, though, is the fact that it has no problems starting in any country--even rich ones. This is mainly because of the Fungus' unique ability, Spore bursts and eruptions. Even if you're unlucky enough to start in cold & rich country like Canada, you'll still be able to recover by evolving spore bursts and infecting poor & hot countries--India is always a great country to be infected at a very early stage.

Although spore burst is, in fact, a great ability, it's still completely random where your spores end up. There are even cases where every spore burst you evolve seem to infect rich countries--needless to say, you do not want that to happen.

List of Guides:

Luckily, some amazing people(including myself) have already made guides for the Fungus plague type. Some made particularly for this scenario, and some made for a normal mega-brutal difficulty game. Don't worry about guides made for normal games, the great thing about Fungus is that you don't really need to start in a good plague-friendly country.

Spicy's Strategy

I have only won three times out of 6 games using this strategy. The losses were mainly because of bad infection orders from spore bursts and eruptions. 

If you're using this strategy for a normal Fungus game, pick India as a starting country. The hot climate of India will give you a bonus in infectivity.

Here's the stats of the last 3 wins I had with this strategy

Gene Setup

  • ATP Boost
  • Aquacyte
  • Patho-Stasis
  • Genetic Mimic
  • Extremophile

1.) Starting country does not matter. If you're using this guide for a normal game of Fungus, start in India. Pop the very first red bubble then immediately evolve 6 Spore Bursts and a Spore Eruption

2.) If you're lucky enough to get India and China in the very first set of spore abilities, you will have a good game. Continue by evolving the following in this order:
  • Rash
  • Sweating
  • Skin Lesions
  • Bird 1
  • Water 1
  • Bird 2
  • Water 2
  • Cold Resistance 1
  • Drug Resistance 1
  • Cold Resistance 2
  • Drug Resistance 2
  • Necrosis
3,) The early mutation of Necrosis isn't really a bad thing, neither is the mutation of anything else. You can choose to devolve 2 mutated symptoms, though, it'll give you a little DNA(Only devolve twice, the third time won't give you any DNA and the succeeding ones will cost you DNA). Continue by evolving these abilities:
  • Heat Resistance 1 & 2
  • Environmental Hardening
4.) At this point, you'll need to periodically check your infection summary spread(World tab-Data) and wait until every country is infected. Once the very last country you need is infected, evolve these lethal symptoms in this order:
  • Hemorrhagic Shock
  • Internal Hemorrhaging
  • Tumours
  • Systemic Infection
  • Coma
  • Total Organ Failure
5.) The symptoms above will be enough to kill people quickly. Remaining DNA is best put towards evolving Genetic Re-Shuffles to slow down the cure progression. 

That's it. I hope this strategy has helped you get those 3 golden biohazards for Fungus in the Unknown Origin scenario.
End of Spicy's Strategy

If you have any strategies or tips you'd like to share, post them at the comment section below. We'll include the most up-voted comments of strategies and tips along with this guide. You can also send your strategies to us via our submit a guide section. HSG!


  1. Great strategy. I also found that this method is a great strategy for Fungus Speed Run. The only change that I made was to evolve all the Spore Abilities, including Spore Hardening right from the beginning. If you want to test that method yourself, feel free. I had good results for it. (260 days)

  2. Not working. IOS 1.9.1.